Climate change is considered to be a significant threat that faces mankind in this century. In Ghana, it isexpected to have a significant effect on agriculture and other climate dependent livelihoods in all ten regionsof the country. The development and implementation of policies on climate change in Ghana require theincorporation of local people’s perception and knowledge of the risks they are exposed to. A study to assessthe perceptions and knowledge of climate change was undertaken in the Offinso Municipality in Ghana. The study used a cross-sectional design where the information gathered represented what was going on at onepoint in time. Respondents (307) were selected from Kwapanin, Koforidua, Kyebi, Sampronso and Anyinasusocommunities using the systematic sampling method. The study used questionnaires, focus group discussionsand targeted interviews to collect primary information on local people’s perception on climate change. Theanalysis used descriptive statistics (frequency and percentages) and chi-square to detect any associationbetween demographic characteristics of local people and their perception of climate change. In addition theknowledge levels of respondents on climate change was analysed. The results indicate that perception ofclimate change is not influenced by origin, gender or level of education; however, it is significantly influencedby age. A knowledge portfolio showed that local people did not have in-depth knowledge on climate change ingeneral. There is therefore the need to create awareness and sensitize local people on causes, indicators andeffects of climate change.